Abstract
• Metabolaid® is a dietary supplement comprising hibiscus and lemon verbena extracts. • Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome. • Phenolic compounds in Metabolaid® were rapidly metabolized by the gut microbiota. • Metabolaid® promoted increases in SCFAs production, particularly butyric acid. This paper investigates the impact of a polyphenol-enriched supplement comprised of hibiscus ( Hibiscus sabdariffa ) and lemon verbena ( Lippia Citriodora ) (brand name Metabolaid®) on gut microbiota composition and functionality, by performing fermentations with human faecal microbiota under gut-simulated conditions. Results indicated that Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome to higher relative abundances of some major genera (>3% of relative abundance) such as Bifidobacterium , Blautia and Faecalibacterium and of other minor genera such as Prevotella and Akkermansia . Metabolaid® also promoted increases in short-chain fatty acids (SCFAs) production, particularly butyric acid. On the other hand, it was confirmed that the compounds present in the Metabolaid® supplement (anthocyanins, verbascoside and hibiscus acid) were rapidly metabolized by the gut microbiota. Overall, these results reveal a certain level of gut microbiota-modulating properties of Metabolaid® that could be implicated, at least partially, in the mechanisms behind the potential beneficial effects of this supplement in obesity.
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