Abstract
The fish digestive system develops primarily from endoderm and mesoderm cells. These are specified before gastrulation at the blastoderm margin and then migrate to the midline. Few endodermal cells are specified and undergo high rates of proliferation. The intestine is the first to become histologically recognizable, followed by the pharynx and esophagus. Maturation of epithelial, mesenchymal, and enteric neurons occurs during the second half of embryogenesis. Pancreas and liver develop during the second half of embryogenesis. Specification of cells that contribute to each of the digestive organs occurs during early somite stages. In this article, zebrafish are used as a model and molecular pathways involved in digestive development are described.
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