Guillain-Barré syndrome associated with SARS-CoV‑2 (analysis of clinical cases)

Abstract

COVID‑19 infection is associated with many neurological complications, one of which is acute autoimmune polyneuropathy or Guillain-Barré syndrome.The aim of this study. To analyze clinical symptoms, electrophysiological parameters, and evaluate the efficacy of therapy for Guillain-Barré syndrome associated with SARS-CoV‑2 viral infection. The relationship between the severity of a previous COVID‑19 infection and the severity of damage to the peripheral nervous system was also studied. The article presents three clinical cases with different pathophysiological variants of the disease.Methods of research. All patients underwent electroneuromyography, lumbar puncture, laboratory tests. In one case, the patient underwent confocal microscopy of the cornea to assess the condition of the corneal nerve fibers.Conclusions. With timely diagnosis and treatment of Guillain-Barré syndrome associated with SARS-CoV‑2 virus, a good recovery of neurological disorders is observed, despite the severity of the viral infection itself