Abstract
Abstract Magnetic Drug Targeting (MDT) is a cancer treatment technique that enables a local chemotherapy. In MDT, chemotherapeutic drugs are bound to magnetic nanoparticles and are accumulated in the tumor area by means of an external magnetic field. Unfortunately, a single magnet can only generate a pulling magnetic force. However, in some applications a pushing force on the nanoparticles could be advantageous. One way to realize pushing forces is to exploit the acoustic radiation force based on the nonlinearity of sound propagation in fluid media generated by a high intensity focused ultrasonic transducer. In this context, we built a test setup was built to investigate the utility of High Intensity Focused Ultrasound (HIFU) to generate a pushing force on the magnetic nanoparticles. The results show that the acoustic radiation force can be employed for particle guidance to achieve concentration differences similar to those obtained by using an electromagnet.
Highlights
A reduction of overall medication dosage to minimize side effects for cancer patients is still a major issue in cancer therapy
Recent investigations have shown that Magnetic Drug Targeting (MDT) is a suitable method for an improved local chemotherapy, as the total medication dosage can be reduced [3]
As the density of iron oxide is higher than the density of blood, we can assume that the acoustic radiation force can be utilized to guide the particles, even though their diameter is in the nanometer range
Summary
A reduction of overall medication dosage to minimize side effects for cancer patients is still a major issue in cancer therapy. Various treatment methods are developed and investigated in laboratory tests concerning their efficacy and feasibility [1], [2]. Recent investigations have shown that MDT is a suitable method for an improved local chemotherapy, as the total medication dosage can be reduced [3]. As the density of iron oxide is higher than the density of blood, we can assume that the acoustic radiation force can be utilized to guide the particles, even though their diameter is in the nanometer range. In order to investigate whether the acoustic radiation force can be applied to guide drug carrying nanoparticles through the vascular system, a test bench was built that emulates the anatomy of the vascular system
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