Abstract
Guanylin peptides (GPs) and their receptor, guanylate cyclase C (GC-C), have recently become a topic of great interest in metabolic research. Guanylin and uroguanylin are the most investigated GPs and they belong to a larger family of natriuretic peptides.
Highlights
Guanylin peptides (GPs), guanylin (GN) and uroguanylin (UGN) belong to the family of natriuretic peptides (NPs), which includes atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP)
guanylate cyclases (GC)-A is a receptor for ANP and BNP, which are mainly released from the atria due to atrial stretch
Other important effects on metabolism are the induction of lipolysis in human adipocytes [3], an increase in the energy expenditure in brown adipose tissue (BAT) and the “browning” of white adipose tissue (WAT) [4], secretion of the adipokine adiponectin [5] and the improvement of insulin sensitivity in muscle and liver [6,7]
Summary
Guanylin peptides (GPs), guanylin (GN) and uroguanylin (UGN) belong to the family of natriuretic peptides (NPs), which includes atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). The major effects of GPs in the kidney are contributed to their activation of the GC-C independent signaling pathway (see later). Research of effects of UGN/GC-C signaling pathway in the brain and their role in metabolism became a hot topic.
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