GSTM3 A/B Polymorphism and Risk for Head and Neck Cancer: A Meta-Analysis

Yu Xu,Weiguo Dong,Jun Wang,Hiromu Suzuki

doi:10.1371/journal.pone.0083851

Yu Xu, Weiguo Dong + Show 2 more

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https://doi.org/10.1371/journal.pone.0083851

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Journal: PloS one	Publication Date: Jan 8, 2014
Citations: 10	License type: CC BY 4.0

Affiliation: Renmin Hospital of Wuhan University, Wuhan University

Abstract

BackgroundGlutathione S-transferase M3 (GSTM3) is an important member of the GSTs that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated between the GSTM3 A/B polymorphism and risk of HNC, however, the results remain controversial. The aim of this meta-analysis is to evaluate the association between the GSTM3 A/B polymorphism and the risk of HNC.MethodsAll eligible case-control studies published up to July 2013 were identified by searching PubMed and Web of Science. The HNC risk associated with the GSTM3 A/B polymorphism was estimated for each study by odds ratios (OR) together with its 95% confidence interval (CI), respectively.ResultsFourteen studies from ten publications with 2110 patients and 2259 controls were included. Overall, the GSTM3 A/B polymorphism was associated with a decreased risk of HNC using the dominant model, homozygote comparison model and heterozygote comparison model (OR = 0.82, 95%CI: 0.71–0.94; OR = 0.67, 95%CI: 0.49–0.94; and OR = 0.84, 95%CI: 0.73–0.97, respectively); besides, in stratification analyses by ethnicity, similar results were observed in Caucasian populations. Stratification by tumor site indicated that the GSTM3 polymorphism was associated with a decreased risk of laryngeal cancer under recessive model and homozygote comparison (OR = 0.52, 95%CI: 0.30–0.89; and OR = 0.50, 95%CI: 0.29–0.87, respectively); By stratifying source of control, decreased cancer risk was observed in hospital-based population under all genetic models (OR = 0.67, 95%CI: 0.56–0.81 for the dominant model; OR = 0.66, 95%CI: 0.46–0.95 for the recessive model; OR = 0.55, 95%CI: 0.37–0.83 for the homozygote comparison model, and OR = 0.70, 95%CI: 0.58–0.84 for the heterozygote comparison model).ConclusionsThis meta-analysis suggests that the GSTM3 A/B polymorphism may be an important protective factor for HNC, especially of laryngeal cancer and Caucasian populations.

Highlights

Head and neck cancer (HNC), including cancers of the oral cavity, pharynx, and larynx, is the sixth most common cancer worldwide [1]
It’s worth noting that there was moderate heterogeneity among overall studies under dominant model, so we conducted stratified analysis by ethnicity, tumor cites and the source of the controls to find the potential sources of heterogeneity and we found that heterogeneity still exists in Caucasian population (I2 = 45%, Pheterogeneity = 0.04), laryngeal cancer (I2 = 58%, Pheterogeneity = 0.04) and mixed head and neck cancer (HNC) (I2 = 72%, Pheterogeneity = 0.03), heterogeneity significantly reduced or removed among oral (I2 = 0%, Pheterogeneity = 0.56), pharyngeal cancer (I2 = 33%, Pheterogeneity = 0.22), population-based population (I2 = 29%, Pheterogeneity = 0.21) and hospital-based populations (I2 = 0%, Pheterogeneity = 0.71)
Loktionov et al [29] found that the Glutathione S-transferase M3 (GSTM3) B variant presence especially in combination with the GSTM1-null genotype is a risk factor for colorectal carcinogenesis, and Holley et al [30] suggested the GSTM3 AA genotype is associated with improved prognosis especially in those with GSTM1 null

Summary

Introduction

Head and neck cancer (HNC), including cancers of the oral cavity, pharynx, and larynx, is the sixth most common cancer worldwide [1]. GSTM3 B allele, having increased transcription potential, enhances detoxification activity of GSTM3-encoded protein [6,7]. This allele has been linked to decreased risk of laryngeal carcinoma [8]. Glutathione S-transferase M3 (GSTM3) is an important member of the GSTs that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated between the GSTM3 A/B polymorphism and risk of HNC, the results remain controversial. The aim of this meta-analysis is to evaluate the association between the GSTM3 A/B polymorphism and the risk of HNC

Methods

Results

Conclusion