Abstract
BackgroundMMP1 is an important member of the MMP endopeptidase family that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC, but their results have been inconsistent. Here, we conducted a meta-analysis to further explore the role of the MMP1 -1607 1G>2G polymorphism in HNC development.MethodsWe identified all eligible studies in the electronic databases of PubMed, ISI Web of Knowledge, MEDLINE, Embase, and Google Scholar (from January 2000 to June 2012). A meta-analysis was performed to evaluate the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC by calculating odds ratios (OR) and 95% confidence interval (CIs).ResultsTwelve studies were included in this meta-analysis. In overall comparison, significant associations were found using the recessive and allelic contrast models (OR, 1.38; 95% CI, 1.07–1.79 and OR, 1.27; 95% CI, 1.05–1.53, respectively), but no association was detected using the dominant model. In the stratified analyses by several variables, significant associations were observed using the recessive, dominant, and allelic contrast models in the Asian population (OR, 1.64; 95% CI, 1.29–2.08; OR, 1.39; 95% CI, 1.06–1.82; and OR, 1.41; 95% CI, 1.21–1.65, respectively), European population (OR, 0.58; 95% CI, 0.40–0.84; OR, 0.64; 95% CI, 0.44–0.92; and OR, 0.68; 95% CI, 0.54–0.85, respectively), and population-based subgroup (OR, 1.24; 95% CI,1.05–1.47; OR,1.48; 95% CI,1.04–2.12; and OR, 1.22; 95% CI, 1.07–1.38, respectively). Furthermore, significant associations were detected in oral cavity cancer and nasopharyngeal cancer under the recessive model.ConclusionOur results suggest that the MMP1 -1607 1G>2G polymorphism is associated with risk of HNC and that it plays different roles in Asian and European populations. Further studies with large sample size are needed to validate our findings.
Highlights
Head and neck cancer (HNC) globally comprises tumors of the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx, and is the sixth most common cancer in the world [1]
We explored the association between the MMP11607 1G.2G polymorphism and risk of head and neck cancer (HNC) using a recessive genetic model (2G/2G versus 1G/1G+1G/2G), a dominant genetic model (2G/2G+1G/2G versus 1G/1G), and an allelic contrast model (2G allele versus 1G allele)
Thirty-four studies were excluded for not meeting the inclusion/exclusion criteria: 25 studies were not relevant to HNC or Matrix metalloproteinase-1 (MMP1); 4 studies did not have sufficient data for further analysis; 4 studies were review articles; and 1 study was an article of comment
Summary
Head and neck cancer (HNC) globally comprises tumors of the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx, and is the sixth most common cancer in the world [1] It is associated with a moderately high recurrence rate, a low survival rate, a high frequency of second primary malignancy (SPM), and a high prevalence of comorbidities [2]. The human MMPs family, which consists of at least 26 proteases, can be divided into several subgroups according to their structure and substrate specificity [11,12] These subfamilies include collagenases, gelatinases, stromelysins, matrilysins, and membrane-type MMPs (MTMMPs), among others. MMP1 is an important member of the MMP endopeptidase family that plays a critical role in the development of head and neck cancer (HNC). We conducted a meta-analysis to further explore the role of the MMP1 -1607 1G.2G polymorphism in HNC development
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