GSTM1 polymorphisms and lung cancer risk in the Chinese population: a meta-analysis based on 47 studies.

Xin-Ping Chen,Wei-Hua Xu,Xian-He Xie,Sheng-Miao Fu,Da-Feng Xu,Jia Yao

doi:10.7314/apjcp.2014.15.18.7741

Xin-Ping Chen, Wei-Hua Xu + Show 4 more

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https://doi.org/10.7314/apjcp.2014.15.18.7741

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Abstract

Although a number of studies have been conducted on the association between GSTM1 polymorphisms and lung cancer in China, this association remains elusive and controversial. To clarify the effects of GSTM1 polymorphisms on the risk of lung cancer, a meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to 5th April 2014. A total of 45 articles (47 studies) including 6,623 cases and 7,865 controls were involved in this meta-analysis. Overall, a significant association (OR = 1.45, 95%CI: 1.32-1.60) was found between the null GSTM1 and lung cancer risk when all studies in Chinese population pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area and source of controls, the same results were observed under all the models. This meta-analysis showed that the null GSTM1 may be a potential biomarker for lung cancer risk in Chinese, but further studies with gene-gene and gene-environment interactions are required for definite conclusions.

Highlights

Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer death in males globally, with 1.6 million newly confirmed cases and 1.4 million deaths from lung cancer annually (Jemal et al, 2011)
Study selection We identified 114 articles that examined the association between glutathione S-transferase M1 (GSTM1) polymorphism and risk of Lung cancer in Chinese
Subgroup analysis In the subgroup analysis based on source of control, the results showed that the GSTM1 polymorphism was significantly related to lung cancer risk among populationbased population (OR = 1.55, 95%confidence interval (CI): 1.39-1.73), as well

Summary

Introduction

Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer death in males globally, with 1.6 million newly confirmed cases and 1.4 million deaths from lung cancer annually (Jemal et al, 2011). Human cancers can be initiated by DNA damage caused by environmental chemical agents, such as polycyclic aromatic hydrocarbons (PAHs), and some adverse habits including tobacco smoking and alcohol use (Neumann et al, 2005). Studies have shown that exposures to environmental and occupational PAHs are risk factors for lung cancer (Kriek et al, 1993; Li et al, 2004; Vineis & HusgafvelPursiainen, 2005). Not all of those who have been exposed to the risk factors will develop lung cancer, suggesting that there is individual variation in cancer susceptibility in the general population (Neumann et al, 2005). Studies have consistently associated the development of lung cancer with the genetic factors such as glutathione S-transferase M1 (GSTM1)

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