Abstract
The X-ray repair cross-complementing group 1 protein (XRCC1) plays important roles in the DNA base excision repair pathway which may influence the development of lung cancer. This study aimed to evaluate the potential association of the XRCC1 c.1178G>A genetic polymorphism with lung cancer risk. The created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods were utilized to evaluate the XRCC1 c.1178G>A genetic polymorphism among 376 lung cancer patients and 379 controls. Associations between the genetic polymorphism and lung cancer risk were determined with an unconditional logistic regression model. Our data suggested that the distribution of allele and genotype in lung cancer patients was significantly different from that of controls. The XRCC1 c.1178G>A genetic polymorphism was associated with an increased risk of lung cancer (AA vs GG: OR=2.91, 95%CI 1.70-4.98, p<0.001; A vs G: OR=1.52, 95%CI 1.22-1.90, p<0.001). The allele A and genotype AA may contribute to risk of lung cancer. These preliminary results suggested that the XRCC1 c.1178G>A genetic polymorphism is statistically associated with lung cancer risk in the Chinese population.
Highlights
Lung cancer is one of the major causes of cancer mortality in the world, with more than a million deaths each year (Guilbert, 2003; Yin et al, 2009; Siegel et al, 2012; Yuan et al, 2013; Wang et al, 2014)
This study aimed to evaluate the potential association of the X-ray repair cross-complementing group 1 protein (XRCC1) c.1178G>A genetic polymorphism with lung cancer risk
The XRCC1 c.1178G>A genetic polymorphism was associated with an increased risk of lung cancer (AA vs GG: odds ratios (ORs)=2.91, 95%confidence intervals (CIs) 1.70-4.98, p
Summary
Lung cancer is one of the major causes of cancer mortality in the world, with more than a million deaths each year (Guilbert, 2003; Yin et al, 2009; Siegel et al, 2012; Yuan et al, 2013; Wang et al, 2014). Several XRCC1 genetic variants, such as Arg194Trp, Arg 280His and Arg399Gln (Giachino et al, 2007; Lopez-Cima et al, 2007; Sreeja et al, 2008; Kalikaki et al, 2009; Yin et al, 2009; Yin et al, 2009; Butkiewicz et al, 2011; Qian et al, 2011; Guo et al, 2013; Letkova et al, 2013; Li et al, 2013; Zhang et al, 2014), have been identified to play potentially influence on the risk of lung cancer in different populations. The purpose of this study is to evaluate the effects of this genetic polymorphism on influencing lung cancer
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