Abstract
•Arrhythmogenic cardiomyopathy is characterized by cardiac arrhythmias, myocardial remodelling, and exercise-induced premature death.•Recent work in a homozygous Desmoglein-2 mutant (Dsg2mut/mut) mouse model of ACM has identified pathogenic roles of increased glycogen synthase kinase-3 (GSK3) activity, calcium (Ca2+) overload, and mitochondrial dysfunction, which ultimately contributes to apoptosis and myocardial remodelling.•GSK3 negatively regulates the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pump, a key regulator of Ca2+ uptake in the heart.•Here, our results demonstrate that the benefits of GSK3 inhibition, previously observed in Dsg2mut/mut mice, could be partly attributed to improvements in cardiac SERCA function.
Published Version
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