Abstract
The influence of the dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106, dosage form) during three-day peroral administration at a dose of 0.1 mg/kg on the 1% sucrose solution preference test and the content of postsynaptic density protein (PSD-95) in the prefrontal cortex and hippocampus of C57Bl/6 mice was studied in an acute three-day social defeat stress model. The preference for sucrose solution decreased and the PSD-95 content in the prefrontal cortex was halved statistically significantly in stressed mice as compared to control animals. The hippocampal PSD-95 content in stressed animals did not change. Anhedonia was completely prevented after each stress session according to the sucrose preference test with peroral administration of GSB-106 at a dose of 0.1 mg/kg once per day for three days. GSB-106 did not reduce the prefrontal PSD-95 content of stressed animals during the experiment.
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