Abstract
SummaryAspects of the carbohydrate metabolism of a strain of serially cultured human diploid cells which fulfill the criteria for normal cells have been studied. These cells show an initial 24-hour lag in cell division and glycolysis upon subcultivation. Following this, cell division proceeds rapidly for 5 to 6 days. Rates of glucose utilization and lactic acid production generally follow the same time course. The glycolytic rate of these cells resembles that of other serially cultured cells.In the absence of added glucose: mannose, galactose and fructose were able to support the growth of human diploid cells. Mannose was converted to lactic acid at almost the same rate as glucose while galactose and fructose were converted to lactate at a somewhat slower rate.
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