Abstract
Feulgen DNA content distribution profiles of cultured human diploid cell strain WI-38 were determined by scanning microdensitometry. Evidence is presented to support the hypothesis that the decline in proliferative activity observed in this system can be attributed to the presence of noncylcing cells. Age-related transitions of cycling cells to a noncylcing state were found to occur with growth period as well as increasing passage level. Since a nonlcycling G 1 blocked cell is a product common to both processes, it is felt that the plateau phase inhibition of proliferation may play a role in the finite lifespan of these cells in vitro.
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