Growth and characterization of 2-(meta-methoxyphenyl) thiazolidine

Abstract

2-(meta-methoxyphenyl) thiazolidine (hereafter called 2mmpT) has medicinal importance, as the five-membered thiazolidine ring happens to be the active part of penicillin. This material has been synthesized and crystallized. The crystals are needle-shaped and of dimensions 0.3 × 0.5 × 1.5mm3 using X-ray diffraction technique, oscillation and Weissenberg patterns of the sample are taken. It is shown that the crystal is monoclinic and the unit cell parameters are found to be a = 1.007(5) nm, b=0.545(3) nm, c=1.720(8) nm and β=71.3(3)°. The space group is P21/c. From IR absorption spectrum of the sample, the characteristic peak pertaining to NH at 3250cm−1 has been identified. The proton magnetic resonance (PMR) spectrum of the sample unambiguously supports the proposed structure of the compound. It has been confirmed that thiazolidine complex in the present case is a cyclic and not a linear one. The implications are discussed.