Abstract
The 16th Annual Natural Health Products Research Conference and Tradeshow hosted by the NHP Research Society of Canada (NHPRS) will be held from May 26-29, 2019 in Edmonton, Alberta. Founded in 2003 by a collaboration of academic, industry, and government researchers from across Canada, the NHPRS is a Canadian federally incorporated non-profit organization. The goals of the NHPRS are; (a) to promote scientifically rigorous research and education on natural health products (NHPs), (b) to develop a national research community that encompasses academic, health professional, government and a broadbase of industry stakeholders, (c) to support national research priorities that best enable the informed and appropriate use of NHPs that are safe and efficacious, (d) to increase the capacity for NHP research and education, (e) to facilitate effective NHP knowledge transfer and translation, (f) to support the use of science-based product quality standards and the use of well-characterized materials and protocols in research and (g) to foster value-chain development through interdisciplinary NHP research collaborations and networking. To forward these objectives, the NHPRS has held annual research conferences since inception with themes that highlight the important trends in the ever growing and changing field of NHP Research. The theme of the 16th Annual Conference is “Growing NHPs for the Future”. The abstracts are ordered alphabetically by presenting author last name, oral presentations followed by poster presentations. For more information, please visit: http://www.nhprs.ca/.
Highlights
The 16th Annual Natural Health Products Research Conference and Tradeshow hosted by the natural health products (NHPs) Research Society of Canada (NHPRS) will be held from May 26-29, 2019 in Edmonton, Alberta
Our research demonstrated in vitro effects on Fatty Acid Amide Hydrolase (FAAH), CB1 and CB2 receptor binding assays
Further tests with CB receptor antagonists AM251 and AM680 co-administrated with Echinacea extract demonstrated a significant reduction of the pharmacological activity
Summary
O01 Biologically Active Natural Products: Discovery, Sar, and Interactions with Protein Targets. This crude extract library has been screened for activity in cell-based and pure enzyme assays designed to identify promising natural product lead compounds for the development of drugs. Bioassay-guided fractionation of crude extracts and extensive spectroscopic analysis has been used to identify the structures of pure natural products active in the assays. Biology-oriented chemical synthesis has been undertaken to probe the SAR (structure-activity relationships) for new natural product pharmacophores that we have discovered and to provide material for in vivo testing in animal models. We have used Click chemistry probes and protein x-ray diffraction analysis to study the interactions of bioactive natural products with their molecular targets. The lecture will present some recent highlights from our academic natural products drug discovery and chemical biology research
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