Abstract
Background: Previous studies have demonstrated psychosocial and physical benefit from exercise for older men treated with androgen deprivation therapy (ADT) for prostate cancer (PCa). To date, different intervention delivery methods have not been assessed. This study compared the effect of group-based exercise (GBE) to personal training (PT) in men undergoing ADT for PCa. Methods: 13 participants (mean age = 68.2, SD = 7.2) were randomly assigned to GBE or PT for 8 weeks. Participants exercised for 60 minutes three times per week at a moderate-vigorous intensity. Results: 10 participants completed the intervention. At post-intervention, the PT group improved: fatigue, systolic BP, waist circumference, body fat percentage, and maximal leg strength; participants in the GBE group improved leg strength. At 8 weeks, maximal upper body strength in the PT group was greater than the GBE group. There were no adverse events associated with moderate-high intensity training in this population of older men. Conclusion: PT may be more efficacious than GBE in improving several physical fitness outcomes and fatigue in men with PCa who are androgen deprived. Due to the small sample size and attrition, these results require cautious interpretation and confirmation from adequately powered trials.
Highlights
In Canadian men, prostate cancer (PCa) is the most common form of cancer and the third leading cause of cancer-related death [1]
Three participants from the group-based exercise (GBE) group did not complete the trial: one participant experienced symptomatic metastatic disease and was withdrawn from the study after 1 week; two other participants indicated that the exercise facility was too far to commute on a regular basis and withdrew from the study after the baseline assessment
Study non-completers were more likely to be smokers than completers, and non-completers were more likely to be in the GBE group
Summary
In Canadian men, prostate cancer (PCa) is the most common form of cancer and the third leading cause of cancer-related death [1]. A common treatment for men with advanced PCa is androgen deprivation therapy (ADT) which may be used for several years or indefinitely [6,7]. Previous studies have demonstrated psychosocial and physical benefit from exercise for older men treated with androgen deprivation therapy (ADT) for prostate cancer (PCa). This study compared the effect of group-based exercise (GBE) to personal training (PT) in men undergoing ADT for PCa. Methods: 13 participants (mean age = 68.2, SD = 7.2) were randomly assigned to GBE or PT for 8 weeks. At post-intervention, the PT group improved: fatigue, systolic BP, waist circumference, body fat percentage, and maximal leg strength; participants in the GBE group improved leg strength. Conclusion: PT may be more efficacious than GBE in improving several physical fitness outcomes and fatigue in men with PCa who are androgen deprived. Due to the small sample size and attrition, these results require cautious interpretation and confirmation from adequately powered trials
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