Abstract
Postoperative atrial fibrillation (POAF) is a serious yet common complication after coronary artery bypass grafting (CABG) surgery. Previous study have identified multiple genetic susceptibility loci for POAF susceptibility after CABG, although some studies are under-powered. However, none of these studies have been conducted among Asians. In current study, we aim to systematically evaluated the previous positive findings for POAF susceptibility after CABG among Chinese population, using a large population-based, two-stage, case-cohort study. From a discovery cohort of 1,348 patients, a total of nine independent loci were evaluated. Six significant SNPs were then assessed in a separately collected validation cohort of 2,000 patients. After adjustment for clinical predictors of POAF, two variants in GRK5 gene (rs4752292, and rs11198893) were replicated with significance were replicated in the validation cohort. The ORs for each additional copy of minor allele were 1.32 (95% CI: 1.15–1.50, P = 5.82 × 10−5) and 1.47 (95% CI: 1.28–1.69, P = 1.16 × 10−7), respectively. In this two-stage independently collected cardiac surgery cohorts, genetic variations in the GRK5 gene are independently associated with POAF risk in patients who undergo CABG surgery in Asians.
Highlights
Postoperative atrial fibrillation (POAF) is a serious yet common complication, a known predictor of in-hospital morbidity and short-term survival after coronary artery bypass grafting (CABG) surgery, occurring in 25% to 40% of patients[1,2,3,4,5]
Considering that race was a surrogate for genetic determinants of POAF susceptibility after CABG due to genetic disparities among racial/ethnic groups[17,18], investigation of previously reported loci in non-European populations may help to evaluate the generalizability of these initial findings and to identify causal variants
Through a comprehensive retrieval of Pubmed for previous positive findings for POAF susceptibility after CABG, we identified nine independent loci, including four loci in G protein-coupledreceptor kinase 5 (GRK5) gene, 3 in 4q25 region, 1 in IL6 gene, and 1 in HSP70 gene
Summary
Postoperative atrial fibrillation (POAF) is a serious yet common complication, a known predictor of in-hospital morbidity and short-term survival after coronary artery bypass grafting (CABG) surgery, occurring in 25% to 40% of patients[1,2,3,4,5]. Druing last 20 years, researchers have evaluated multiple genetic susceptibility loci for POAF susceptibility after CABG, some studies are under-powered[11,12,13,14,15,16]. All of these studies have been conducted among people of European ancestry. Considering that race was a surrogate for genetic determinants of POAF susceptibility after CABG due to genetic disparities among racial/ethnic groups[17,18], investigation of previously reported loci in non-European populations may help to evaluate the generalizability of these initial findings and to identify causal variants. We conducted this study to evaluated the previous positive findings for POAF susceptibility after CABG among Chinese population
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