ögren syndrome complicated with liver damage and itsrelated factors

Abstract

：Objective To studyclinical features of liver damage in primary Sj(o)gren syndrome (pSS) and its relatedfactors.Methods One hundred and forty-nine patients of confirmed pSS hospitalized atPeking University People's Hospital were analyzed retrospectively.Results Seventeen of 149patients of pSS (11.4%) showed liver damage,10 diagnosed as autoimmune hepatitis and sevenas primary biliary liver cirrhosis.Increased serum levels of IgG,IgM and γ-globulinaccounted for 88.2% and 50.8%,35.3% and 5.3%,and 94.1% and 47.7% of those complicated withand without liver damage,respectively,with statistically significant difference (P ＜ 0.05).Positive serum anti-mitochondria antibody subtype M2 (AMA-M2)was 35.3% in pSS patients with liver damage,significantly higher than that in thosewithout liver damage (1.5%) (P ＜ 0.05).Independent riskfactors significantly associated with liver damage included age (OR = 1.013,95% CI0.971-1.058),course of illness (OR = 1.089,95% CI 1.032-1.150),serum level of γ-globulin(OR = 4.021,95% CI 1.246-12.982),positive AMA-M2 (OR = 11.82,95% CI 0.005-0.157),andpositive anti-SSA (OR = 101.333,95% CI 12.653-811.560).Conclusions Liver damage occurredrather high in pSS patients and increased serum levels of IgG,IgM,γ-globulinand anti-SSA can be used to predict their complication with liver damage.Age,course ofillness,serum level of γ-globulin,positive AMA-M2 and positive anti-SSA are all significantly associatedwith liver damage in pSS patients. Key words: Sj(o)gren's syndrome; Hepatitis,autoimmune; Livercirrhosis,biliary