Clinical study on anticentromere antibody and anti.SSA antibody in patients with Primary Sjogren＇s Syndrome

Abstract

Objective To investigate the clinical and laboratory characteristics of anticentromere antibody （ACA）and anti-SSA antibody expressions in patients with Primary Sj（o）gren＇s Syndrome （PSS）. Methods Twelve PSS patients with ACA positive but SSA negative（ACA PSS）and 19 PSS patients with SSA positive but ACA negative（SSA PSS）were enrolled into the study and classified into two groups. We compared the age,laboratory data,occurrence of Raynaud＇s phenomenon（RP）,and histological changes in minor labial salivary glands biopsies of the patients from two group. Results The mean age of the ACA PSS group（68.4 ± 7.9）years was significantly higher than that of the SSA PSS（54. 6 ± 16. 2）years group（P 〈 0. 05）. Serum IgG level of ACA PSS group（17. 89 ±4. 08）g/L was close to the normal range,which was significantly lower than that of SSA PSS（27.90 ±6. 72）（P 〈0. 01）. Leukocytopenia was less frequently observed in ACA PSS than in SSA PSS（P 〈 0. 05）,the difference between two groups was statistically significant. We also found more frequent RP in the ACA PSS group than SSA PSS group（P 〈 0. 05）. Conclusions Our data confirm that ACA positive PSS differs from SSA positive PSS at several clinical respects and laboratorial examinations. Key words: Primary Sj（o）gren＇s syndrome Anticentromere antibody Anti-SSA antibody