Abstract
An expeditious synthesis of novel 3,4-dihydropyrimidin-2(1H)-one derivatives has been developed using a multi-component reaction involving the in situ generation of non-commercial β-ketoesters via transesterification of tert-butyl-β-ketoester with corresponding alcohol followed by the Biginelli reaction with arylaldehyde and urea in one-pot at 110 °C under green conditions.
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