Green synthesis of starch-mediated CuO nanoparticles: preparation, characterization, antimicrobial activities and in vitro MTT assay against MCF-7 cell line

Abstract

The main goal of this study was the synthesis of copper oxide nanoparticles with a green method using Starch extracted from Solanum tuberosum. The synthesized copper oxide nanoparticles were characterized by different techniques, including X-ray diffraction (XRD), UV–Vis spectrophotometry, and scanning electron microscopy (SEM). All the analyses exposed that the nanoparticles were highly stable and spherical with mean size about 54 nm. The potential antibacterial activity of the copper oxide nanoparticles synthesized in the eco-friendly approach was tested against some standard strains of human pathogens (Gram-positive and -negative bacteria). Efficient antibacterial activities against Bacillus cereus 9634, Shigella sonnei, Staphylococcus epidermidis 1435, Enterococcus 1237, Pseudomonas aeruginosa PAO1 27853 and Escherichia coli 25922 and no significant antibacterial activity against Staphylococcus aureus 2592 were observed. Moreover, MTT assay demonstrated the anticancer activity ofthat the synthesized CuO nanoparticles against MCF-7 cell line.