Green Synthesis of Selenium Nanoparticle from Medicinal Plant Extract and its Potential in The Treatment of Lung Cancer

Abstract

Lung cancer is the leading cause of death globally with an estimated 238,340 people in 2023. Mukia madrespatana, a plant with ethnomedicinal properties, exhibits numerous therapeutic effects in traditional medicine. In recent years there has been a growing interest in utilizing selenium nanoparticles synthesized by green mediated approach involving the plant for treating various types of cancer. Despite notable advancements made in the past decade there are still inherent challenges associated with these treatment approaches. Notably, recent investigations have unveiled promising prospects in the realm of lung cancer treatment through the discovery of antitumor drugs derived from selenium, a trace element. Selenium nanoparticles can serve as a viable option for drug delivery systems, facilitating the precise control of protein kinase activity and they have been found to exhibit regulatory effects on immunity and have shown promise in enhancing immunotherapy for lung cancer