Green synthesis of copper nanoparticles and their evaluation for antimicrobial activity and bio-compatibility

Abstract

Developing antimicrobial resistance by microorganism is one of the major concerns of modern society. The emergence of antimicrobials resistance in bacteria against commonly used effective antibiotics results in the need for stronger and costly therapy. Nanoparticles seem to be a viable solution to tackle the problem of antibiotic resistance in bacteria. As the most of the nanoparticles was use more than one mechanism to kill microorganism. Here, the study was planned to synthesize plant extract mediated CuO nanoparticles with antimicrobial property using green synthesis method. The synthesized nanoparticles were characterized using the UV–vis spectrophotometer, Scanning electron microscope, and Fourier transfer infrared spectroscopy. Schefflera arboricola based synthesized nanoparticles were shows antimicrobial activity against gram negative (E. coli, P. aeruginosa) and Gram positive (B. subtilis,) group of bacteria. Human blood lymphocytes shows normal growth when in presence of Schefflera arboricola leaves extract based synthesized nanoparticles.