Green synthesis and inhibitory effect of novel quinoline based thiazolidinones on the growth of MCF-7 human breast cancer cell line by G2/M cell cycle arrest

Abstract

Searching for new active molecules against human breast cancer cell line MCF-7, novel quinoline based thiazolidinones has been efficiently synthesized under ultrasound irradiation. The newly synthesized compounds were tested against human breast cancer cell line MCF-7. Compounds P3, P4, and P6 were found to be promising inhibitors of MCF-7 characterized by lower IC50 values in a dose-dependent mode with high specificity against MCF-7 (IC50 of 10 μM at 24 h). Among all the synthesized compounds, P3, P4, and P6 shows IC50 values 5.38, 5.12, and 0.73 µM, respectively, were considered as a potential lead. These lead molecules showed significant anti-cancer activity against human breast cancer cell line MCF-7. Additionally, induction of G2/M cell arrest within 24 h was discovered via flow cytometry analysis. Overall, our data suggest that potent compounds have an inhibitory effect on cell proliferation of MCF-7 through cell cycle arrest, giving it great potential as a future therapeutic reagent for cancers.