Green decorated of gold nanoparticles on calcium lignosulfonate modified magnetic nanoparticles mediated by Cydonia oblonga extract: Investigation of its catalytic efficiency and its performance to treat the human esophageal cancer

Abstract

This report documents an eco-friendly and sustainable protocol towards the in situ synthesized Au NPs adorned over calcium lignosulfonate (CLS) functionalized magnetite NPs, being templated by Cydonia oblonga plant extract (Fe3O4/CLS/Au NPs), followed by the evaluation of its chemical and biological properties. Physicochemical characteristics of the bio-synthesized material was assessed using an array of advanced techniques like FT-IR, SEM, TEM, EDX, elemental mapping, VSM and ICP-OES. The prepared Fe3O4/CLS/Au nanomaterial displayed an excellent catalytic performance in the formylation of amine derivatives to the related N-formyl amines. The prepared Fe3O4/CLS/Au was isolated magnetically from the reaction medium and recycled for 9 times without any significant decrease in catalytic activity. In the medicinal part, the anticancer properties of Fe3O4/CLS/Au against human esophageal cancer cell lines were determined. The IC50 of the Fe3O4/CLS/Au were 327, 228, 318, 289, 238, 208, 347, and 213μg/mL against human esophageal cancer (KYSE-30, KYSE-50, KYSE-70, KYSE-270, SK-GT-4, OE33, ESO26, and FLO-1) cell lines.