Abstract
Addressing the recommendations of the 12 basic lows of green chemistry, the microwave technique was utilized in phospha-Mannich, Diels-Alder and inverse Wittig type reactions, moreover under solventless conditions. In the phase transfer catalysed alkylation of CH-acidic compounds, the quaternary onium salts could be substituted by MW irradiation. The effect of chiral phase transfer catalysts was compared on suitable, potentially enantioselective model reactions. Mono- and bidental P-ligands were developed to make available novel platinum complexes that can be useful as catalysts. Finally, esterifications including diesterifications were studied by in situ Fourier Transform IR spectroscopy.
Highlights
1 Introduction These days it is a serious challenge for organic chemists to provide chemical industry including, among others, pharmaceutical industry with environmentally safe synthetic procedures and technologies applying suitable starting materials and atomic-efficient reactions
The reaction components may be irradiated in solvents with suitable dielectric constant or without any solvent
First we studied the phospha-Mannich condensation of secondary amines including N-heterocycles, paraformaldehyde and >P(O)H species, such as diethyl phosphite and diphenylphosphine oxide to afford aminomethylenephosphonates or aminomethylene-phosphine oxides 1
Summary
1 Introduction These days it is a serious challenge for organic chemists to provide chemical industry including, among others, pharmaceutical industry with environmentally safe synthetic procedures and technologies applying suitable starting materials and atomic-efficient reactions. Shortening the reaction times by the application of suitable heat transfer; Development of phase transfer catalytic techniques and application in selective syntheses; Keywords green chemistry · microwave · phase transfer catalysis · Pligands · transition metal complexes · in situ FTIR
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