Abstract
An ecofriendly, magnetically retrievable amine-functionalized SiO2@Fe3O4 catalyst was successfully synthesized and affirmed by several physicochemical characterization tools, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), vibrating sample magnetometry (VSM), energy-dispersive X-ray spectroscopy (EDX), and powder X-ray diffraction. Thereafter, the catalytic performance of this environmentally benign NH2@SiO2@Fe3O4 catalyst was investigated in the one-pot multicomponent synthesis of 2-amino-4H-benzo[b]pyran derivatives. The reaction was simply achieved by grinding of various substituted aromatic aldehydes, dimedone, and malononitrile at room temperature under solvent and waste-free conditions with excellent yields and high purity. Moreover, the developed catalyst not only possesses immense potential to accelerate the synthesis of bioactive pyran derivatives but also exhibits several remarkable attributes like broad functional group tolerance, durability, improved yield, reusability, and recyclability. Besides, various other fascinating advantages of this protocol are milder reaction conditions, cost effectiveness, short reaction time, and simple work up procedures.
Highlights
Benign methods like high efficiency, selectivity, high yield, and simple reaction procedures have become the most important targets to achieve in the field of organic chemistry
The catalytic efficiency of NH2@ SiO2@Fe3O4 (ASMNPs) was investigated in the synthesis of tetrahydrobenzo[b]pyran analogues, and the reaction conditions were optimized in terms of the amount of catalyst, reaction time, and yields
We have successfully synthesized a variety of tetrahydrobenzo[b]pyrans in good to excellent yields using efficient and economic amine-functionalized magnetic nanoparticles under solvent and waste-free reaction conditions
Summary
Benign methods like high efficiency, selectivity, high yield, and simple reaction procedures have become the most important targets to achieve in the field of organic chemistry. Which can in turn cause corrosion, safety issues, and pollution problems In this context, one-pot mechanochemical reactions, i.e., reactions attained by grinding the reactants altogether using a mortar and pestle ( known as “grindstone chemistry”) offers significant advantages such as no column chromatography, no tedious work up, cost effectiveness, and less reaction time over multistep reactions.8a
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