Abstract
Grazing-angle Fourier transform infrared reflection−absorption spectrometry (IRRAS) using a fiber-optic accessory has been investigated as a potential in situ technique for the detection and quantification of contamination by active pharmaceutical agents on glass and metal surfaces. Two methods were used for contamination preparation: one based on smearing a known amount of sample, in solution, onto the substrate and the other by spraying the substrate with an aerosol of the analyte in a volatile solvent. Chemometric calibrations using partial least-squares (PLS) regression are presented and evaluated for acetaminophen on aluminum and glass, and ibuprofen on aluminum and stainless steel. The results indicate that surface loadings of 0.05 μg/cm2 is a readily achievable limit of detection for the IRRAS technique.
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