Abstract
Extremely high dose (g/kg) of Congo red has been reportedly used in assessing the testicular effects of this dye in mice and rats based on prenatal exposure. In our experience, low doses (mg/kg) have produced hepatotoxic effects in chickens and serum enzyme inhibition in rats following oral and intraperitoneal administration. Thus the objective of this study was to find out if our low doses can cause testicular toxicity. Hence the effect(s) of orally administered low doses of Congo red (CR) on rat testes was investigated using gravimetric and histologic methods. When compared to CR-free rats, the testes weights of rats exposed to 10, 20, 30 and 40mg CR/kg body weight (once a week for 6 weeks) significantly decreased (p Key words: Congo red, rat testicular changes Journal of Medical Laboratory Science Vol.12(2) 2003: 42 - 46
Published Version
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