Graphitic carbon nitride infused with PVA-Mn:ZnS modified carbon sensor for electrochemical investigation of Metoclopramide hydrochloride

Abstract

The primary focus is on determining the trace amount of Metoclopramide hydrochloride (MCH) which widely used to treat gastrointestinal disorders such as gastroparesis and acid reflux. The present study involves the development of a novel carbon paste-based sensor modified with Poly vinyl alcohol capped Manganese-doped ZnS nano particles decorated g-C3N4 nanocomposite (PVA-Mn:ZnS/g-C3N4@CPE), for the detecting and investigation of MCH. Cyclic voltammetry (CV) and square wave voltammetry (SWV) were used to measure the electrochemical performance of MCH. The limit of detection and quantification is found to be 5 nM and 16 nM respectively. Using the SWV technique in pH 7.0 phosphate buffer, the examination of urine and water spiked with MCH was monitored. When PVA-Mn:ZnS/g-C3N4 nanocomposite was used as a modifier in electrode-based sensors, results in well-resolved peaks and improved electrochemical current sensitivity. The electrode material was characterized by CV, scanning electron microscopy, atomic force microscopy, and electrochemical impedance spectroscopy. The electro-oxidation of MCH was explored using electro-kinetic characteristics such as heterogeneous rate constant, accumulation time, entropy, enthalpy, Gibbs free energy and other parameters like scan rate and pH. A suitable mechanism was proposed for the number of protons and electrons involved in the electro oxidation of MCH.