Granulosa Cell Tumor in a Farm-Reared Channel Catfish

Abstract

Abstract Multiple white-to-tan, solid, nodular masses were present in the abdominal cavity of a subadult female farm-reared channel catfish Ictalurus punctatus. The masses ranged in size from pinpoint to approximately 1 cm in diameter and were present on the ovaries, liver, spleen, posterior kidney, serosal surface of the intestine, and peritoneal adipose tissue. Histologically, the masses consisted of sheets and packets of large (approximately 12.5–10 × 10–7.5 μm) polyhedral cells with abundant foamy cytoplasm arranged in cords and short interweaving bundles and separated by fine fibrovascular tissue. The nuclei were small to medium in size, round, and pale, often having a distinct nucleolus and rare mitotic figures. The widespread ovarian involvement together with cytological and pattern features is most consistent but not definitive for a gonadal stromal cell tumor (granulosa cell tumor).