Granulomatous dermatitis with focal sarcoidal features associated with recombinant interferon β-1b injections

Abstract

Adverse cutaneous eruptions during recombinant interferon β-1b (rIFN β-1b) injections have included contact dermatitis, erythema nodosum, exfoliative dermatitis, furunculosis, hirsutism, leukoderma, lichenoid dermatitis, maculopapular rash, psoriasis, seborrhea, benign skin neoplasm, skin carcinoma, skin hypertrophy, skin necrosis, skin ulcer, urticaria, and vesiculobullous lesions.1 However, sarcoidlike dermatitis has never been reported. We describe the first case to our knowledge of a cutaneous eruption occurring during rIFN β-1b therapy that histologically resembled sarcoidal granulomas, but without distinctive features of true sarcoidosis.