Abstract
GR-RNF43 Regulation In Colorectal Cancer
Highlights
Analyses of gene expression levels generally focus on differential expression between two conditions
The TACSTD2 gene was shown to be significantly expressed in patientderived breast cancer samples when compared to a wider range of controls and the significance of TACSTD2 for breast cancer cells was confirmed experimentally in MCF7 and MDA-MB-231 breast cancer cell lines [3, 4]
This study does not suggest that either the pairwise or multiple comparison approach is superior, but rather suggests that they provide different sets of genes that could be integrated to offer a more robust list of important genes. The overlap between these different approaches found only one common gene for colorectal cancer, NR3C1 (GR), between the Unlike previous studies that identified specific genes based on the gene expression level changes by comparing tumor to only normal samples, we identified differentially expressed genes specific to colorectal www.openaccesspub.org | JPGR
Summary
Analyses of gene expression levels generally focus on differential expression between two conditions. The overlap between these different approaches found only one common gene for colorectal cancer, NR3C1 (GR), between the Unlike previous studies that identified specific genes based on the gene expression level changes by comparing tumor to only normal samples, we identified differentially expressed genes specific to colorectal www.openaccesspub.org | JPGR This study provides a comparative analysis and suggests that integrating different approaches to determine differentially expressed genes could provide novel mechanistic insight for a condition of interest.
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