Abstract
G-Quadruplexes in the Biology of Eukaryotic Cells
Highlights
Watson and Francis Crick in 1953, the DNA molecule consists of two polynucleotide chains wound around each other to form a clockwise double helix
This structure is known as B form of DNA, B-DNA, and is the predominant conformation adopted by the DNA under relaxed conditions
The DNA molecule can transiently adopt other non-B or non-canonical structures. How these non-B DNA structures are folded in vivo and, what are the cellular conditions that favor the folding of such alternative structures are key questions for fully understanding the role of DNA structural polymorphism in biological processes
Summary
G-Quadruplexes in the Biology of Eukaryotic Cells Watson and Francis Crick in 1953, the DNA molecule consists of two polynucleotide chains wound around each other to form a clockwise double helix. This structure is known as B form of DNA, B-DNA, and is the predominant conformation adopted by the DNA under relaxed conditions.
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