Abstract
Photodynamic therapy (PDT) has received extensive attention in tumor treatment due to its advantages in overcoming drug resistance for chemotherapy. In this work, we prepared a nanoplatform generated from graphene quantum dots capped in hollow mesoporous silica nanoparticles (GQDs/hMSN). The singlet oxygen (1O2) generation efficiency and photodynamic therapy effect of GQDs/hMSN were studied in vitro and in vivo. GQDs/hMSN had good 1O2 generation yield in water. Based on the findings from cellular experiments, we concluded that doxorubicin (DOX) loaded GQDs/hMSN (GQDs/hMSN(DOX)) had synergistic chemo-photodynamic therapeutic effect. From in vivo therapy on HeLa tumor-bearing mice, GQDs/hMSN exhibited significant accumulation in the tumor site, where DOX was also released from the nanoplatform due to the unique tumor microenvironment. This work further confirmed the usefulness of GQDs/hMSN nanoplatform as a potentially useful vector for combinational therapy of cancer.
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