GPR15LGregulates psoriasis-like inflammationby down-regulating inflammatory factors on keratinocytes.

Abstract

Psoriasis is a common chronic inflammatory skin disease characterized by aberrant proliferation of keratinocytes and infiltration of immune cells. We previously found that GPR15LGprotein is highly expressed in psoriasis lesional skin and it positively regulates psoriatic keratinocyte proliferation. Our data also showed that GPR15LGcould regulate the activity of NF-κBpathway which is associated with psoriatic inflammation. In current study, we demonstrated that Gpr15lg(ortholog of GPR15LG) knockdown attenuated the severity of imiquimod (IMQ)-induced psoriasis-like inflammation in mice. Such an effect was achieved by down-regulating the expression of inflammatory cytokines interleukin (IL)-1α, IL-1β,tumor necrosis factor (TNF)-αand S100A7.Consistently, GPR15LGknockdown in vitrosignificantly downgraded the expression of inflammatory factors in the cellular model of psoriasis. These results suggested that GPR15LG could be involved in the development of psoriasis by regulating inflammation.