Abstract
We welcome the work of Landi and colleagues, who used previously published data to replicate a single nucleotide polymorphism (SNP), rs2352028, and risk of lung cancer in never smokers.1 To validate (or refute) a SNP that has gone through discovery and replication in four independent studies, a more homogenous and adequately powered study is needed, with complete epidemiological data (eg, passive smoking, previous chronic obstructive pulmonary disease [COPD] diagnosis, and family history of lung cancer) to control for potential biases in the initial results.
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