Abstract
Methods We identified 72 girls diagnosed with central precocious puberty, and they were treated with GnRH analogue (GnRHa) to suppress pubertal progression from 1 January 2011 to 31 January 2012. GnRH stimulation tests were done before and 4 weeks after the third dose of the GnRH analogue. Information on clinical manifestations and laboratory data were obtained by reviewing medical records. All variables were expressed as mean +/SD, and a p value of <0.05 was considered statistically significant.
Highlights
Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard to document premature activation of the hypothlamic-pituitary-gonadal axis in early puberty
We identified 72 girls diagnosed with central precocious puberty, and they were treated with GnRH analogue (GnRHa) to suppress pubertal progression from 1 January 2011 to 31 January 2012
1) Before GnRHa treatment, the mean luteinizing hormone (LH) level was higher at the 30th minutes (18.17 IU/L±16.77) of the test in comparison to the basal level (0.35 IU/L ± 0.60), the 15th, 60th, 90th and 120th minutes (p
Summary
Gonadotropin-releasing hormone (GnRH) stimulation test before and after GnRH analogue treatment in central precocious puberty; can GnRH test simplify adequately? Purpose Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard to document premature activation of the hypothlamic-pituitary-gonadal axis in early puberty. This test is time-consuming, costly and uncomfortable for the patients. The aim of this study was to investigate to simplify the GnRH stimulation test in the assessment of pubertal activation and suppression.
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