Abstract
Correlation of the gonadal position and mullerian duct derivative regression was estimated in 17 patients with ambiguous genitalia and dysgenetic gonads. Six out of ten testes located at or beyond the internal inguinal ring were not associated with fallopian tubes on the same side. Four of those six testes were cryptorchid, including two that were located at the internal inguinal ring. All six intra-abdominal testes were associated with an ipsilateral fallopian tube. These findings can be explained by the two-stage model of testicular descent where migration from the posterior abdominal wall to the internal inguinal ring, the transabdominal phase, is closely related to mullerian duct regression, suggesting a role for mullerian inhibiting substance in this phase.
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