Abstract
Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of intratumoral microvessel density (MVD) by counting CD-34 positive immunostained endothelial cells. Correlations of expression with MVD, clinicopathologic features and clinical prognosis were analyzed. A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. However, we do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), although higher MVD was positively associated with GOLPH3 overexpression (p<0.001). Expression of GOLPH3 was found to be an independent prognostic factor in early- stage NSCLC patients, those expressing high levels of GOLPH3 exhibiting a substantially lower 5-year overall survival than GOLPH3-negative patients (adjusted HR =1.899, 95% CI: 1.021-3.532, p=0.043). High expression of the GOLPH3 protein is common in early-stage NSCC, and is closely associated with tumor progression, increased tumor angiogenesis, and poor survival. We conclude a possibility of its use as a diagnostic and prognostic marker in early-stage NSCC patients.
Highlights
Lung cancer is the leading cause of death among the malignant tumors worldwide, and the incidence of lung cancer is increasing (Travis, 2011)
We do not find any correlation between Golgi phosphoprotein-3 (GOLPH3) expression and clinicopathologic features (p>0.05), higher microvessel density (MVD) was positively associated with GOLPH3 overexpression (p
The mammalian target of rapamycin has emerged as a critical effector in cell-signaling pathways commonly deregulated in human cancers
Summary
Lung cancer is the leading cause of death among the malignant tumors worldwide, and the incidence of lung cancer is increasing (Travis, 2011). There is an urgent need to identify novel biomarkers that will help select the patients with high chance of lung cancer recurrence and provide better prognosis and individualization treatment. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Results: A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. We do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), higher MVD was positively associated with GOLPH3 overexpression (p
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