Abstract
The optical properties and electric field enhancement of gold nanorods for different cases were investigated in this study. The numerical analysis was carried out to understand the functionality and working of gold nanorods, while the experimental portion of the work was focused on the efficiency of gold nanorods for targeted drug delivery. COMSOL Multiphysics was used for numerical analysis. The theoretical results suggest the use of gold nanorods (AuNRs) for anticancer applications. The resonance peaks for gold nanorods of 10 nm diameter were observed at 560 nm. The resonance peaks shifted towards longer wavelengths with an increase in nanorod size. The resonance peaks showed a shift of 140 nm with a change in nanorod length from 25 to 45 nm. On the experimental side, 22 nm, 35 nm and 47 nm long gold nanorods were produced using the seed-mediated growth method. The surface morphology of the nanorods, as well as their optical characteristics, were characterized. Later, gold nanorods were applied to the targeted delivery of the doxorubicin drug. Gold nanorods showed better efficiency for doxorubicin drug loading time, release time, loading temperature, and release temperature. These results reveal that AuNRs@DA possess good ability to load and deliver the drug directly to the tumorous cells since these cells show high temperature and acidity.
Highlights
The optical characteristics of gold nanoparticles (AuNPs) are different from their bulk materials
The numerical analysis of electric field enhancement and optical properties of gold nanorods was conducted for biological applications
For identically sized gold nanorods, the resonance peak amplitude redshifts as the refractive index of the surrounding medium rises
Summary
The optical characteristics of gold nanoparticles (AuNPs) are different from their bulk materials. Au nanocrystals possess a special light focusing capacity They show good ability to focus the free-space optical field in subwavelength areas under resonant simulation close to their surfaces [8,9]. As a result of their tiny size, these nanocarriers have favorable physiochemical and biological properties [31] They are very powerful carriers of targeted DDS that successfully transport drugs towards a specific biological location. These nanocarriers are widely used in DDS because of their increased bioavailability [32], active surface area [33], solubility in biofluids [34], rapid anti-cancer therapeutic efficacy [35], and decrement in the dose [36]. The numerical analysis of electric field enhancement and optical properties of gold nanorods was conducted for biological applications. Doxorubicin was used for targeted drug delivery via AuNRs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
