Gold Nanoparticles/Two-Dimensional (2D) Hexagonal Boron Nitride Nanosheets Including Diethylstilbestrol Imprinted Polymer: Electrochemical Detection in Urine Samples and Validation

Abstract

A new diethylstilbestrol (DES) imprinted sensor approach based on gold nanoparticles (AuNPs) incorporated two-dimensional (2D) hexagonal boron nitride (2D-hBN) nanosheets was presented for DES detection. The methods such as scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) method, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for all nanomaterials’ characterizations. DES imprinted sensor was prepared in presence of 100.0 mM pyrrole containing 25.0 mM DES by CV. The developed method was validated and 5.0 × 10−12−1.0 × 10−8 M and 1.0 × 10−13 M were founded as the linearity range and the detection limit (LOD). DES imprinted glassy carbon electrode (GCE) was applied in presence of the natural estrogens such as estrone (E1), estradiol (E2) and estriol (E3) and the other agents such as hydroquinone (HYD) and catechol (CAT).