Abstract
For the widely used anticancer, antiinflammatory, and immunosuppressant drug 6-thioguanine (6-TG), its unique photochemistry of absorbing UVA, generating singlet oxygen (1O2), and inducing oxidative DNA damage can cause severe phototoxicity side effects in biomedical applications. Here we raise a new strategy of loading 6-TG onto gold nanoparticles (AuNPs) and demonstrate from systematic ultraviolet irradiation experiments that the 6-TG photochemistry can be successfully modulated by binding with AuNPs and the phototoxicity under UVA irradiation are effectively removed, not only for single base 6-TG but also for 6-TG embedded in DNA. In conjunction with excited state ab initio calculations, the molecular mechanisms are further unveiled, accounting for the protection effects of AuNPs in prohibiting the 6-TG photoactivation and 1O2 oxidation. These findings point to tremendous possibilities of using AuNPs as inert carrier to modify excited state photochemistry and prevent unwanted phototoxicity effects of t...
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