Abstract
Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, gold nanoparticles (Au NPs) make excellent drug and anticancer agent carriers in biomedical and cancer therapy application. Recent advances of synthetic technique improved the surface coating of Au NPs with accurate control of particle size, shape and surface chemistry. These make the gold nanomaterials a much easier and safer cancer agent and drug to be applied to the patient’s tumor. Although many studies on Au NPs have been published, more results are in the pipeline due to the rapid development of nanotechnology. The purpose of this review is to assess how the novel nanomaterials fabricated by Au NPs can impact biomedical applications such as drug delivery and cancer therapy. Moreover, this review explores the viability, property and cytotoxicity of various Au NPs.
Highlights
Gold nanoparticles (Au NPs) are effective radiosensitizers in medical applications such as drug delivery and cancer therapy
In biomedical and cancer therapy applications, Au NPs can act as a contrast agent and dose enhancer in image-guided nanoparticle-enhanced radiotherapy using kilovoltage cone-beam computed tomography [1,2]
High stability and prolonged blood circulation was obtained by PEGylation, which allowed for the effective accumulation of carriers in targeted tumors, resulting in outstanding intra-tumor gene silencing efficiency in brain cells, and the theory was tested on tumor-bearing mice and showed promising results [86]
Summary
Gold nanoparticles (Au NPs) are effective radiosensitizers in medical applications such as drug delivery and cancer therapy. The integration of functional ligands as coating through surface chemistry on the NPs enables them to perform multiple biomedical functions in the molecular or cellular level simultaneously Applications of these nanomaterials include contrast agents in multimodal imaging, carriers in drug delivery and enhancers in cancer therapy. NPs havedrug given insight molecular on how to diagnosis for disease detection and nanoscale immunotherapy These areas show high potential for develop new targeted therapies, systemic cancer treatments and identification of novel oncogenic future clinical implementation [8]. This makes Au NPs act as molecular sensors, therapeutic agents, and vehicles for imaging agent and.
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