Abstract
Lysozyme serves as a crucial biomarker in the identification of several diseases, that includes breast cancer, Alzheimer’s disease, meningitis, and rheumatoid arthritis. This study proposes an innovative method for the detection of Lysozyme using a gold nanoparticle based biosensor and decomposition Muller matrix polarimetry. In the proposed study, the DNA aptamer is used as the recognition element, while the gold nanoparticles are used as a sensing element. The sensed signal is taken as the input to a Mueller matrix calculation process, which determines three optical characteristics that yield optimal results of the gold nanoparticle colloidal solution, namely the degree of depolarization, the linear diattenuation, and the depolarization index. The results have shown that all three optical parameters vary linearly with the concentration of Lysozyme throughout a broad dynamic range spanning from 0.01 to 500 pM with a limit of detection of 1.24 fM. Overall, the proposed technique provides potential tool for the detection of Lys.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
