Abstract
In the context of elevated morbidity and mortality risk of heart failure (HF), the establishment of prompt and sensitive diagnosis of HF is vital. A nanostructured fluorescence immuno sensing probe was constructed out of noble metal nanoclusters / two-dimensional transition metal dichalcogenide nano couple to target brain natriuretic peptide (BNP) antigen, a potential multi-utility heart failure biomarker. The green fluorescence of BNP-specific monoclonal antibody-conjugated gold nanoclusters was pre-quenched by a MoS2 two-dimensional nanosheet, which is subsequently enhanced in the presence of BNP antigen via target-specific antigen–antibody interaction. The probe is free from interferences by other potentially interfering possible co-existing biomolecules and offers easy, low-cost linear detection of BNP in the concentration range 0 to 360.82 pg/mL.
Published Version
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