Abstract
The complexes [(AuCl)2dadpe](1) and [Au(dadpe)2]Cl (2) where dadpe is Ph2PCH2CH2AsPh2 have been prepared and characterized by n.m.r. spectroscopy (31P-{1H}, 1H, and 13C-{1H}) and by X-ray crystallography. 31P-{1H} N.m.r. spectroscopy shows that complex (1) is converted into (2) on titration with dadpe in CDCl3 at a Au: dadpe ratio of 1:2. At higher ratios there is exchange between complex (2) and the excess of ligand. Such rapid ligand exchange is also indicated by the 1H n.m.r. data. Crystals of (1) are monoclinic, space group Cc with a= 19.385(3), b= 11.011(2), c= 27.260(1)A, β= 96.40(1)°, and Z= 8. The ligand co-ordinates two AuCl chains with intermolecular Au ⋯ Au contact of 3.21 A. The P and As atoms are disordered and there appears to be conformational flexibility about the ethane bridge. Crystals of (2) are monoclinic, space group P21/n, a= 10.192(1), b= 21.797(7), c= 21.683(10)A, β= 94.14(3)°, and Z= 4 and contain bis chelated AuI in a distorted-tetrahedral environment; again the P and As atoms are disordered. Complexes (1) and (2) are significantly more toxic towards L1210, WS, and V.79 cells in vitro than is the free ligand, dadpe, and are comparable to [Au(dppe)2]Cl in their toxicity towards WS and V.79 cell lines.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
