Abstract
A gold-catalyzed cycloisomerization/nucleophilic addition/C-O rearrangement was developed starting from readily available pyrrole precursors. This efficient synthesis of 7,8-dihydroindolizin-6(5H)-ones (with the creation of new C-C and C-O bonds) allows access to key intermediates for the synthesis of natural and biologically active molecules. The functionalization process was independently optimized for both carbon and oxygen nucleophiles, and the versatility of this methodology was established by the synthesis of 36 different pyrrole derivatives (yields up to 90%).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
