Abstract
Differences in the global methylation pattern, i.e., hyper- as well as hypo-methylation, are observed in cancer, including germ cell tumors (GCTs). Related to their precursor cells, the GCT methylation status differs according to histology. We investigated the methylation pattern of normal fetal, infantile, and adult germ cells (n = 103) and GCTs (n = 251) by immunohistochemical staining for 5-mCytidine. We found that the global methylation pattern of male germ cells changes from hypomethylation to hypermethylation, while female germ cells remain unmethylated at all stages.
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