Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

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MA Sadat, S Moir, TW Chun. N Engl J Med. 2014;370(17):1615–1625 The goal of this study was to elucidate viral resistance despite immunodeficiency in a rare congenital disorder of glycosylation type IIb. The study subjects were 2 siblings presenting with multiple neurologic complications and a paradoxical immunologic phenotype characterized by severe hypogammaglobulinemia but limited clinical evidence of recurrent severe infections. An 11-year-old …